Xanthohumol

Xanthohumol

 

Xanthohumol is part of our diet mainly in the form of beer or beer mix drinks. Due to the thermal conversion of Xanthohumol to the isoflavanone isoxanthohumol during the brewing process, the concentration of xanthohumol in beer, however, is very low

 

In 2002, we identified xanthohumol as a broad-spectrum cancer chemopreventive agent acting by multiple mechanisms relevant for the prevention of carcinogenesis in the initiation, promotion and progression phase

 

has been the subject of over 75 research papers due to its role as a cell protector, preventative phytochemical, and as a potentially longevity-enhancing compound.

 

some scientists and researchers believe is 200 times more powerful than Resveratrol

 

Xanthohumol may bind to GABA receptors and induce relaxation.

 

Xanthohumol has been characterized a `broad-spectrum’ cancer chemopreventive agent in in vitro studies

 

prenylflavonoids from hops have potential for application in cancer prevention programs and in prevention or treatment of (post-)menopausal `hot flashes’ and osteoporosis

 

Safety after long-term application is a very important issue for compounds intended for the prevention of chronic diseases. Hussong et al. demonstrated weak hepatotoxicity when xanthohumol was applied for four weeks at a daily dose of 1000 mg/kg per day to female SD rats (8). At a 10-fold lower concentration (in drinking water), however, xanthohumol did not show any toxic effects

 

Anti-estrogenic effects of xanthohumol were confirmed in vivo. In an uterotrophy assay with prepubertal rats, xanthohumol treatment (100 mg/kg bw/day) lowered unstimulated as well as ethinylestradiol-induced uterine weights by about 30% (11). Xanthohumol did not cause any adverse effect on female reproduction and on the development of offspring when given either for four weeks prior to or during mating, gestation and nursing. Treatment of male rats prior to mating significantly (p = 0.027) increased the sex ratio of male to female offspring (9).

 

http://www.dkfz.de/en/tox/c010-2_projects/xanthohumol.html

 

“our data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent,“

 

like curcumin, quercetin, and resveratrol, xanthohumol is another extremely powerful anti-aging compound.

 

Xanthohumol inhibits growth and vascularization of developing endometriotic lesions.

 

 

The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration.

 

Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor.

 

Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways.

 

Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A).

 

Xanthohumol decreases Notch1 expression and cell growth by cell cycle arrest and induction of apoptosis in epithelial ovarian cancer cell lines.

 

Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells.

 

Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis.

 

Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells.

 

Xanthohumol enhances antiviral effect of interferon alpha-2b against bovine viral diarrhea virus, a surrogate of hepatitis C virus.

 

 

Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.

 

In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris.

 

improve mitochondrial function

 

act as an antiinfective agent against microorganisms including bacteria, viruses, fungi and malarial protozoa. XN was shown to inhibit the Gram-positive bacteria Staphylococcus aureus and Streptococcus mutans. Antiviral activity was demonstrated against bovine viral diarrhea virus, cytomegalovirus, herpes simplex virus type 1 and 2 and human immunodeficiency virus 1. Inhibition of two Trichophyton spp. was indicative of antifungal activity. Finally, XN potently inhibited the replication of Plasmodium falciparum, the causative agent of malaria.

 

inhibit invasion of triple negative breast cancer cells

 

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.   The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome.

 

Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis

hop flavonoids may have anti-breast cancer effects

 

In conclusion, this study demonstrates for the first time that in addition to its originally being considered an agent preventing tumor growth, xanthohumol possesses potent neuroprotective activity.

 

Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice.

The ability of XN to inhibit prostate cancer in vitro and in vivo suggests that XN may be a novel agent for the management of prostate cancer.

 

Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor.

 

This study demonstrates for the first time that xanthohumol possesses potent antiplatelet activity.  Therefore, this novel role of xanthohumol may represent a high therapeutic potential for treatment or prevention of cardiovascular diseases.

 

Was reported to inhibit the proliferation of the human breast cancer cell line MCF7.

 

Has anti-obesity activity

 

Has antiviral, antifungal and antibacterial activity

 

Was found to prevent the cytopathogenic effects of HIV (i.e. prevents damage to cells)

 

Anti-osteoporosis activity: was reported in one study to prevent bone resorption

 

Research summary in “PDF for nutritional supplements”

 

is antiestrogenic without possessing intrinsic estrogenic potential. 

 

Although hops is commonly linked with phytoestrogenic effects, we identified XN as a pure estrogen antagonist. Interestingly, XN may also reduce the generation of estrogens by inhibition of the enzymatic activity of aromatase, which converts testosterone to estrogen. Anti-estrogenic effects of XN (100 mg/kg body weight/day) were confirmed in vivo

 

Xanthohumol is anti-estrogenic, while hops is estrogenic.

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